Elevated or decreased blood glucose concentration is a harmful condition for the human body. A hormone secreted from the beta-cells of pancreatic islands regulates glucose levels. Glucose control impairment occurs in some autoimmune diseases.
For example, diabetes disease can cause fluctuations in blood sugar. Type 1 of this disease is an autoimmune condition characterized by immune-mediated destruction of insulin-producing pancreatic cells resulting in a lack of insulin. In the absence of insulin, patients can suffer from severe hyperglycemia. So, with this disease, one needs to be vigilant on the adequate sugar level.
On the flip side, in someone who has undiagnosed diabetes, blood sugar values that are too high, leading to tiredness and even fainting, might signal diabetes.