Fever is also an important systemic symptom of lupus. It happens in over 50 percent of individuals. Fever is due to active disease but can also result from infections or drug reactions. One frequent presentation in the history of lupus is episodic fever. In the case of an exacerbation of the disease, the temperature rises periodically and then drops to normal values.
Persistent fever, on the other hand, can also occur during this process and may be a sign that the disease is targeting the central nervous system. These patients are in an immunocompromised state, so infections need to be ruled out first during diagnosis. However, doctors are unable to find the source of the fever and mistakenly attribute it to a rare fever of unknown origin in patients who have not been diagnosed with lupus.
