It has been noted that lupus can involve musculoskeletal systems. More than 90% of patients have joint-related symptoms. Joint symptoms are frequently the initial presentation of the disease. Patients will mostly state that they suffer from joint pain rather than arthritis. However, mild inflammation may be noted. Typically, the inflammation will be treated by several joints, especially the small joints of the hands, knees, and wrists, but any joint can be affected.
Patients typically rate joint pain as mild. Joint destruction is not common. The pain patients feel can be extremely uncomfortable. Consequentially, lupus patients may develop fibromyalgia and generalized pain. Muscle and joint pain can be multi-focal and is a significant burden for the patients.
